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Traumatic Brain Injury
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Introduction
Intranasal administration via the Shenocatheter allows exosomes to bypass the blood–brain barrier through the olfactory and trigeminal pathways. Neural exosomes may support neuroinflammation reduction, neuronal repair and signaling.
Indications and Viable Conditions
Mild, moderate, or severe traumatic brain injury
Post-concussive syndrome
Chronic neurologic symptoms following head trauma
Cognitive dysfunction, headaches, mood or sleep disturbance related to TBI
Contraindications
Active sinus or nasal infection
Severe nasal septal deviation
Active intracranial hemorrhage (relative contraindication)
Dosing Considerations
Total Dose: 2.0 cc EXO-NeuralTM
1.0 cc per nostril
Procedure:
1. Position patient supine with slight neck extension.
2. Prime SphenoCatheter® per manufacturer guidelines.
3. Advance catheter along nasal floor to posterior nasopharynx.
4. Deliver 1.0 cc EXO-NeuralTM slowly.
5. Repeat on contralateral side.
6. Maintain supine position for 10–15 minutes post-procedure.
Treatment Frequency
Initial Series: Every 2 weeks for 4–8 weeks (2–4 treatments)
Maintenance: Every 4–8 weeks as clinically indicated
Regulatory Disclaimer
This therapy is investigational. Exosome-based products are not FDA-approved for the treatment of traumatic brain injury. This protocol is not intended to diagnose, treat, cure, or prevent disease.
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